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ChemInform Abstract: Synthesis and Characterization of Chiral 1,2-Diamines from 5-Oxo-pyrrolidine-(S)-2-carboxylic Acid.

โœ Scribed by Uwe Koehn; Andrea Schramm; Florian Kloss; Helmar Goerls; Evelyn Arnold; Ernst Anders


Publisher
John Wiley and Sons
Year
2008
Weight
32 KB
Volume
39
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Synthesis and Excha
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Synthesis and Exchange Reactions of 5-Alkyl-2-oxo-6-thioxo-1,2,3,6-Tetrahydropyrimidine-4-carboxylic Acids. -The title compounds are prepared as potential dihydroorotase inhibitors. H/D-exchange studies establish a high tendency towards epimerization at C-5. No epimerization is observed under physi