ChemInform Abstract: Synthesis and Cardiotonic Activity of Pyrazolylpyrimidines.
โ Scribed by V. SEDEREVICIUTE; V. GARALIENE; P. VAINILAVICIUS; A. HETZHEIM
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 35 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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โฆ Synopsis
Synthesis and Cardiotonic Activity of Pyrazolylpyrimidines.
-The title compounds are screened for cardiotonic activity. Many of them exhibit positive effects. The most positive-inotropic effects show compounds (VIII). The ED 50 values are comparable to those of milrinone. -(SEDEREVICIUTE, V.;
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In vivo Cardiotonic Activity of Pyridylmethylene-2-indolinones. -5-Chloro-3-pyridylmethylene-2-indolinone (III) is synthesized and subjected to an in vivo cardiotonic assay along with some previously described analogues. Structure-activity relationships are discussed. -(ANDREANI, A.;