Several new 1,2,5-oxadiazole N-oxide derivatives were synthesized to be tested both as potential selective hypoxic cell cytotoxins and as DNA-binding agents. The compounds prepared included bis(1,2,5-oxadiazole N-oxide) derivatives and oxadiazole rings linked to naphthyl residues. The compounds were
ChemInform Abstract: Synthesis and Biological Evaluation of 1,2,5-Oxadiazole N-Oxide Derivatives as Potential Hypoxic Cytotoxins and DNA-Binders.
โ Scribed by Hugo Cerecetto; Mercedes Gonzalez; Mariela Risso; Gustavo Seoane; Adela Lopez de Cerain; Olga Ezpeleta; Antonio Monge; Leopoldo Suescun; Alvaro Mombru; Ana M. Bruno
- Publisher
- John Wiley and Sons
- Year
- 2001
- Weight
- 33 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0931-7597
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Synthesis and Biological Evaluation of 1,2,5-Oxadiazole N-Oxide Derivatives as Hypoxia-Selective Cytotoxins. -Synthesis and biological evaluation of a series of new 1,2,5-oxadiazole N-oxide derivatives [cf. (IV), (V), (VIII), (X) (30 examples)] with potential cytotoxic effects are described. Compoun
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a โFull Textโ option. The original article is trackable v