Synthesis and antiviral activity of 2-de
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MarΓa-JesΓΊs PΓ©rez-PΓ©rez; Erik De Clercq; Piet Herdewijn
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Article
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1996
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Elsevier Science
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English
β 210 KB
Nucleoside analogues containing a 2-deoxy-l,5-anhydro-D-mannitol and a pyrimidine base moiety were synthesized starting from D-glucose via a nucleophilie opening of an epoxide with the heterocyelic base and an inversion of configuration at the 3'-position. Study of the conformation of these molecule