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ChemInform Abstract: Synthesis and Antimalarial Activity of DL-Deoxyferbrifugine.

โœ Scribed by Yasuo Takeuchi; Shin-ichiro Tokuda; Tomoko Takagi; Midori Koike; Hitoshi Abe; Takashi Harayama; Yasuharu Shibata; Hye-sook Kim; Yasuke Wataya

Publisher
John Wiley and Sons
Year
2010
Weight
26 KB
Volume
30
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

is remarkably lower than that of febrifugine and isofebrifugine bearing a hydroxy group at the piperidine ring.

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Synthesis and Activity of Some Antimalarial Bisquinolinemethanols. -Ongoing interest in the development of novel antimalarial agents leads to the synthesis of compounds such as (III) and (VIII). Among all compounds the derivative (VIIIb) shows high biological activity, but the toxicity of this subs