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ChemInform Abstract: Synthesis and Anticholinesterase Properties of Diacetylene Diamines.

โœ Scribed by N. M. LIBMAN; S. G. KUZNETSOV; V. I. ZLOBINA; S. N. MORALEV; B. N. KORMILITSYN; N. S. ANDROSOV

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
30
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Synthesis and Anticholinesterase Properties of Diacetylene Diamines.

-All diacetylene diamines (VI), synthesized by Mannich reaction of ฮฑ,ฯ‰-diacetylenes with amines and formaldehyde, possess non-selective anticholinesterase activity. It is shown, that the biological activity is reduced in sterically strained tertiary amines like N-benzyl derivative (VIc). Introduction of a diphenylpolymethylene bridge [cf. compound (VIb)], however, increases

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