ChemInform Abstract: Syntheses of 2′,3′-Dideoxy-D-C-nucleosides from γ-Lactone.

✍ Scribed by Y. XIANG; J. DU; C. K. CHU

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 35 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199738266

✦ Synopsis

Syntheses of 2',3'-Dideoxy-D-C-nucleosides from γ-Lactone.

-A versatile method for the synthesis of 2',3'-dideoxy-D-C-nucleosides such as (X)/(XI) and (XVII)/(XVIII) starting from γ-lactone (I) is presented. None of the target compounds shows significant activities against HBV and HIV as well as significant toxicities. -(XIANG, Y.;