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ChemInform Abstract: Substituted Indole-1-acetic Acids as Potent and Selective CRTh2 Antagonists — Discovery of AZD1981 (I).

✍ Scribed by Tim Luker; et al. et al.

Publisher
John Wiley and Sons
Year
2012
Weight
20 KB
Volume
43
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Discovery of 4-{1-[
ChemInform Abstract: Discovery of 4-{1-[({1- [4-(Trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino] cyclopropyl}benzoic Acid (MF-766), a Highly Potent and Selective EP4 Antagonist for Treating Inflammatory Pain.
✍ Yongxin Han; et al. et al. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 18 KB

## Abstract The synthesis of the second generation EP~4~ antagonist MF‐766 (I) is accomplished in four steps from an easily accessible methyl indolecarboxylate.