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ChemInform Abstract: Studies on Disease-Modifying Antirheumatic Drugs: Synthesis of Novel Quinoline and Quinazoline Derivatives and Their Antiinflammatory Effect.

✍ Scribed by A. BABA; N. KAWAMURA; H. MAKINO; Y. OHTA; S. TAKETOMI; T. SOHDA

Publisher: John Wiley and Sons
Year: 2010
Weight: 33 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199716185

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✦ Synopsis

Studies on Disease-Modifying Antirheumatic Drugs: Synthesis of Novel Quinoline and Quinazoline Derivatives and Their Antiinflammatory Effect.

-A variety of compounds such as (V) (20 examples) and (IX) (7 examples) are synthesized and their structure-activity relationships examined with regard to the antiinflammatroy effect in rats with adjuvant arthritis. Most of these compounds exhibit a potent effect with (IX) being the most effective one. It is selected as a candidate for further investigations.

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