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ChemInform Abstract: Studies on Disease-Modifying Antirheumatic Drugs. Part 3. Bone Resorption Inhibitory Effects of Ethyl 4-(3,4-Dimethoxyphenyl)-6,7-dimethoxy-2- (1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate (TAK-603) and Related Compounds.

โœ Scribed by Atsuo Baba; Tsuneo Oda; Shigehisa Taketomi; Kohei Notoya; Atsushi Nishimura; Haruhiko Makino; Takashi Sohda

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
30
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Studies on Disease-Modifying Antirheumatic Drugs. Part 3. Bone Resorption Inhibitory Effects of Ethyl 4-(3,4-Dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate (TAK-603) and Related Compounds.

-Structure-activity relationships concerning the bone resorption inhibitory effects of compounds (I) are reported. TAK-603 (Id) is effective in preventing bone loss in ovariectomized mice.

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