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ChemInform Abstract: Structure—Activity Study and Analgesic Efficacy of Amino Acid Derivatives as N-Type Calcium Channel Blockers.

✍ Scribed by Takuya Seko; Masashi Kato; Hiroshi Kohno; Shizuka Ono; Kazuya Hashimura; Hideyuki Takimizu; Katsuhiko Nakai; Hitoshi Maegawa; Nobuo Katsube; Masaaki Toda


Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
32
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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✍ K. YOSHIIZUMI; S. IKEDA; N. NISHIMURA; K. YOSHINO 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB

Synthesis and Structure-Activity Relationships of Thienylcyanoguanidine Derivatives as Potassium Channel Openers. -A series of thienylcyanoguanidine derivatives [cf. (V), (X), (XIII)] is synthesized and evaluated for their smooth muscle relaxation activity in vitro. Among the newly synthesized comp