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ChemInform Abstract: Structure—Activity Relationship of Homochiral 7-Substituted 1-Aminoindans as 5-HT1A Receptor Ligands

✍ Scribed by D. LANDSIEDEL-MAIER; A. W. FRAHM

Publisher: John Wiley and Sons
Year: 2010
Weight: 32 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199820129

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## Abstract Conformational restriction of naftopidil led to the discovery of a new class of ligands with a 1,3‐dioxolane (1,3‐oxathiolane, 1,3‐dithiolane) structure that bind to α~1~ adrenoceptor subtypes and 5‐HT~1A~ receptors. Adequate structural modifications address the selectivity toward one o