ChemInform Abstract: Structure of the Complex Between Phosphorylated Substrates and the SCF β-TrCP Ubiquitin Ligase Receptor: A Combined NMR, Molecular Modeling, and Docking Approach.

The third-dimensional structure of the c

The third-dimensional structure of the complex between an Fv antibody fragment and an analogue of the main immunogenic region of the acetylcholine receptor: A combined two-dimensional NMR, homology, and molecular modeling approach

✍ Jens Kleinjung; Marie-Christine Petit; Piotr Orlewski; Avgi Mamalaki; Socrates J 📂 Article 📅 2000 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 351 KB 👁 2 views

## Binding of autoantibodies to the acetylcholine receptor (AChR) plays a major role in the autoimmune disease Myasthenia gravis (MG). In this paper, we propose a structure model of a putative immunocomplex that gives rise to the reduction of functional AChR molecules during the course of MG. The mo