ChemInform Abstract: Sterically Biased 3,3-Sigmatropic Rearrangement of Chiral Allylic Azides: Application to the Total Syntheses of Alkaloids.
β Scribed by Sophie Lauzon; Francois Tremblay; David Gagnon; Cedrickx Godbout; Christine Chabot; Catherine Mercier-Shanks; Stephane Perreault; Helene DeSeve; Claude Spino
- Publisher
- John Wiley and Sons
- Year
- 2008
- Weight
- 48 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0931-7597
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The Phenanthrenone Approach to Opium Alkaloids: Formal Total Synthesis of Morphine by Sigmatropic Rearrangement. -Eschenmoser-Claisen rearrangement of alcohol (II) and ring closure reaction of epoxide (VII) to give the desired E-ring are the key steps in the preparation of the morphine synthon (VII