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ChemInform Abstract: Stereoselective Synthesis of Functionalized Pyroglutamates.

✍ Scribed by Matthew J. Just; Srinivas Tekkam; Mohammad A. Alam; Subash C. Jonnalagadda; Joseph L. Johnson; Venkatram R. Mereddy

Publisher
John Wiley and Sons
Year
2012
Weight
32 KB
Volume
43
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

A highly diastereoselective alkylation of threonine‐based oxazoline (I) becomes possible with Baylisβ€”Hillman‐derived allyl bromides or Baylisβ€”Hillman acetates.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Novel Methodologies
ChemInform Abstract: Novel Methodologies for the Synthesis of Functionalized Pyroglutamates.
✍ Srinivas Tekkam; M. A. Alam; Subash C. Jonnalagadda; Venkatram R. Mereddy πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons βš– 39 KB πŸ‘ 1 views

## Abstract A series of pyroglutamates (III), (VIII), and (X) is readily prepared by reaction of iminoesters (I) with corresponding Baylisβ€”Hillman derivatives followed by acidic cleavage of imines and a subsequent lactamization.