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ChemInform Abstract: Novel Methodologies for the Synthesis of Functionalized Pyroglutamates.

✍ Scribed by Srinivas Tekkam; M. A. Alam; Subash C. Jonnalagadda; Venkatram R. Mereddy

Publisher
John Wiley and Sons
Year
2011
Weight
39 KB
Volume
42
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

A series of pyroglutamates (III), (VIII), and (X) is readily prepared by reaction of iminoesters (I) with corresponding Baylis—Hillman derivatives followed by acidic cleavage of imines and a subsequent lactamization.

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ChemInform Abstract: Stereoselective Syn
ChemInform Abstract: Stereoselective Synthesis of Functionalized Pyroglutamates.
✍ Matthew J. Just; Srinivas Tekkam; Mohammad A. Alam; Subash C. Jonnalagadda; Jose 📂 Article 📅 2012 🏛 John Wiley and Sons ⚖ 32 KB

## Abstract A highly diastereoselective alkylation of threonine‐based oxazoline (I) becomes possible with Baylis—Hillman‐derived allyl bromides or Baylis—Hillman acetates.