ChemInform Abstract: Stereoselective Syntheses of Epothilones A and B via Directed Nitrile Oxide Cycloaddition.
β Scribed by Jeffrey W. Bode; Erick M. Carreira
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 32 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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π SIMILAR VOLUMES
Total Syntheses of Epothilones A and B. -Distinct ring-forming strategies for the convergent stereocontrolled synthesis of the microtubule-stabilizing title macrolides (I) are developed.
## Synthesis of Epothilones: Stereoselective Routes to Epothilone B. -In continuation of studies concerning the total synthesis of epothilones, efficient routes to epothilone B (I) using a macro-lactonization and a metathesis approach are detailed.