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ChemInform Abstract: Stereoselective Amination of 5-Substituted γ-Lactones and γ-Lactams. A Convenient Route for the Preparation of 5-Substituted (3S,5S)-3-Acetylaminotetrahydrofuran-2-ones and (3S,5S)-3-Acetylaminopyrrolidin-2-ones.

✍ Scribed by Marko Skof; Jurij Svete; Matej Kmetic; Simona Golic-Grdadolnik; Branko Stanovnik


Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
30
Category
Article
ISSN
0931-7597

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Stereoselective Amination of 5-Substitut
✍ Marko S'kof; Jurij Svete; Matej Kmetič; Simona Golič-Grdadolnik; Branko Stanovnik 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 249 KB

5-Substituted (S)-tetrahydrofuran-2-ones (1a,b) and (S)-catalytic hydrogenation, into the corresponding 5-substituted (3S,5S)-3-acetylaminotetrahydrofuran-2-ones (4a,b) and pyrrolidin-2-ones (1c,d) were transformed in three steps, by treatment with tert-butoxybis(dimethylamino)methane (Bre-(3S,5S)-3