ChemInform Abstract: Stereocontrolled Total Synthesis of Hemibrevetoxin B.

✍ Scribed by I. KADOTA; Y. YAMAMOTO

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 28 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199906234

✦ Synopsis

Stereocontrolled Total Synthesis of Hemibrevetoxin B. -A linear approach to the total synthesis of title compound (I) is accomplished with high stereoselectivity in 56 steps and 0.75% overall yield from D-mannose. Key step in this synthesis is the intramolecular reaction of γ-alkoxyallylstannanes with aldehydes which is demonstrated to be a powerful tool for the construction of polycyclic ethers. -(KADOTA, I.;