ChemInform Abstract: (-)-Sparteine-Mediated Asymmetric Intramolecular Carbolithiation of Alkenes: Synthesis of Enantiopure Cyclopentanes with Three Consecutive Stereogenic Centers.
β Scribed by Dieter Hoppe; Michael J. Woltering; Martin Oestreich; Roland Froehlich
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 34 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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Asymmetric Synthesis of Ξ²-Hydroxy Esters Having Three Consecutive Chiral Centers with a Reductase from Bakers' Yeast. -The title reaction is investigated with Ξ²-keto esters (I) having a secondary alkyl group at the Ξ±-position. The corresponding Ξ²-hydroxy esters can be isolated in excellent enantios