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ChemInform Abstract: (-)-Sparteine-Mediated Asymmetric Intramolecular Carbolithiation of Alkenes: Synthesis of Enantiopure Cyclopentanes with Three Consecutive Stereogenic Centers.

✍ Scribed by Dieter Hoppe; Michael J. Woltering; Martin Oestreich; Roland Froehlich


Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
31
Category
Article
ISSN
0931-7597

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Asymmetric Synthesis of Ξ²-Hydroxy Esters Having Three Consecutive Chiral Centers with a Reductase from Bakers' Yeast. -The title reaction is investigated with Ξ²-keto esters (I) having a secondary alkyl group at the Ξ±-position. The corresponding Ξ²-hydroxy esters can be isolated in excellent enantios