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ChemInform Abstract: Simplified Analogues of Ritanserin and Their Affinity at 5-HT2A, 5-HT2B, and 5-HT2C Serotonin Receptors.

✍ Scribed by F. CLAUDI; L. SCOCCIA; G. GIORGIONI; G. MARUCCI; A. DI STEFANO; S. GESSI; A. SINISCALCHI; P. A. BOREA

Publisher: John Wiley and Sons
Year: 2010
Weight: 33 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199904144

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✦ Synopsis

Simplified Analogues of Ritanserin and Their Affinity at 5-HT 2A , 5-HT 2B , and 5-HT 2C Serotonin Receptors. -A variety of derivatives of 4-[bis(4-fluorophenyl)methylene]piperidine (I) are synthesized and evaluated for their affinity at 5-HT serotonin receptors. The compounds (I) show lower binding affinity than the parent compound ritanserin thus demonstrating that the thiazolepyrimidinone moiety of ritanserin seems to be necessary for binding interaction at 5-HT receptors.

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