Simplified Analogues of Ritanserin and Their Affinity at 5-HT 2A , 5-HT 2B , and 5-HT 2C Serotonin Receptors. -A variety of derivatives of 4-[bis(4-fluorophenyl)methylene]piperidine (I) are synthesized and evaluated for their affinity at 5-HT serotonin receptors. The compounds (I) show lower binding
ChemInform Abstract: 4-(4-Fluorobenzoyl)-1-[2-(4-iodo-2,5-dimethoxyphenyl)ethyl]piperidine and Its Derivatives: Synthesis and Affinity at 5-HT2A, 5-HT2B and 5-HT2C Serotonin Receptors.
✍ Scribed by Francesco Claudi; Loredana Scoccia; Gianfabio Giorgioni; Beatrice Accorroni; Gabriella Marucci; Stefania Gessi; Anna Siniscalchi; Pier Andrea Borea
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 39 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
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## Abstract magnified image A series of novel ligands for the serotonin 5‐HT~2A/C~ receptor subtype bearing the 2‐phenylethylamine pharmacophore was synthesized and assayed for its 5‐HT~2A~ receptor binding affinity. As the 4′‐aryl‐substituted 2‐(2,5‐dimethoxyphenyl)ethylamines were previously unk
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v