ChemInform Abstract: Several Approaches to Cyanide Ion-Catalyzed Synthesis of 4-Aroyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidines.

✍ Scribed by A. MIYASHITA; Y. SUZUKI; K. OHTA; K. IWAMOTO; T. HIGASHINO

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 29 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199816151

✦ Synopsis

Several Approaches to Cyanide Ion-Catalyzed Synthesis of 4-Aroyl-1-phenyl-1H-pyrazolo [3,4-d]pyrimidines.

-The reaction of the 4-chloropyrimidine (I) with aromatic aldehydes (II) gives the 4-aroyl derivatives (III) in the presence of catalytic p-toluenesulfinate and potassium cyanide. The yields are substantially higher compared to the reactions using catalytic KCN only. Furthermore, the analogous 4-tosylpyrimidine (IV) provides good yields using KCN as sole catalyst, showing the tosyl group to be a more effective leaving group. -(MIYASHITA, A.;