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ChemInform Abstract: Semisynthesis of RPR 121056A, a Major Metabolite of Irinotecan (CPT-11) .

โœ Scribed by J.-D. BOURZAT; M. VUILHORGNE; L. P. RIVORY; J. ROBERT; A. COMMERCON

Book ID
112040840
Publisher
John Wiley and Sons
Year
2010
Weight
26 KB
Volume
27
Category
Article
ISSN
0931-7597

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Synthesis of Sibutramine, a Novel Cyclobutylalkylamine Useful in the Treatment of Obesity, and Its Major Human Metabolites. -A short and convenient pathway to sibutramine (VII) and some of its demethylated (cf. (V)) and hydroxylated (cf. (XI)) human metabolites is presented. One of the key steps is