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ChemInform Abstract: Ring-Opening Addition Reactions of 1-tert-Butoxycarbonyl-3,4-epoxypiperidine with Amine Nucleophiles.

✍ Scribed by Boja Poojary; Hee-Jong Lim


Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
41
Category
Article
ISSN
0931-7597

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The N-benzyl-and N-alkyl-substituted 1,2-thiazetidin-3-one 1,1-dioxides 1b Β± d reacted readily with NH 3 and primary amines via ring opening. The reaction with NH 3 proceeded at Γ€ 788 3 room temperature yielding ring-opened adducts via nucleophilic attack of NH 3 at the sulfonyl group, whereas the r