ChemInform Abstract: Ring-Closing Metathesis in Methanol and Water.

✍ Scribed by Thomas A. Kirkland; David M. Lynn; Robert H. Grubbs

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 33 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199925044

✦ Synopsis

Ring-Closing Metathesis in Methanol and Water.

-Using watersoluble ruthenium alkylidene catalysts (I) or (II) a ring-closing metathesis of acyclic dienes can be achieved in protic solvents such as methanol (or water). Generally, better results are obtained with catalyst (I). α,ω-Unsubstituted dienes [cf. (IIIe)] do not cyclize because of the instability of the resulting methylidene. -(KIRKLAND,