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ChemInform Abstract: Regioselective Synthetic Approaches Towards 1,2,8,9-Tetraazadispiro[4.1.4.3]tetradeca-2,9-dien-6-ones.

✍ Scribed by A. S. Girgis; Y. A. Ibrahim; N. Mishriky; J. N. Lisgarten; B. S. Potter; R. A. Palmer

Publisher: John Wiley and Sons
Year: 2010
Weight: 28 KB
Volume: 32
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200133131

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In order to prepare new tacrine-like compounds, the title compounds (VII), (X) and (XV) are synthesized. The synthetic pathway to (VII) represents a shorter and more suitable approach to prepare tacrine metabolites. An alternative route from (VIb) to compound (VIII), which exhibits very strong DNA b