ChemInform Abstract: Regioselective N-Alkylation of 2-Aminobenzylamine via Chelation to 9-BBN.

✍ Scribed by G. BAR-HAIM; M. KOL

• Book ID: 101866014
• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 29 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199829098

✦ Synopsis

Regioselective N-Alkylation of 2-Aminobenzylamine via Chelation to 9-BBN.

-Base-promoted alkylation of the easily available adduct (III) of 9-BBN and 2-aminobenzylamine results in high yield formation of a mono-substituted product (V). Final hydrolysis with HCl or NaOH leads to 2-amino-N-alkylbenzylamines (VI). -(BAR-HAIM, G.;