In order to define the structural requirements of quinazoline-2(1H)-thiones 1 for their inhibitory activity on melanogenesis, a novel series of 3,4-dihydroquinazoline-2(1H)-thiones (3a-h) were prepared and screened for their melanogenesis inhibition on melanoma B16 cell line under the stimulant of a
β¦ LIBER β¦
ChemInform Abstract: Refinement of the Pharmacophore of 3,4-Dihydroquinazoline-2(1H)-thiones for Their anti-Melanogenesis Activity.
β Scribed by Pillaiyar Thanigaimalai; Vinay K. Sharma; Ki-Cheul Lee; Cheong-Yong Yun; Youngsoo Kim; Sang-Hun Jung
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 29 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0931-7597
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## Abstract New 2,3βdihydroquinazolinβ4(1H)βones combined with either chalcone (III), pyrazole (IV), or thiazole (VIII) moieties are synthesized and evaluated for their analgesic and antiinflammatory activity.