ChemInform Abstract: Rearrangement of 2-Amino-4-(trifluoromethyl)oxazoles to Hydantoins.

✍ Scribed by Jon P. Lawson; Karey A. VanSant

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 29 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199930137

✦ Synopsis

Rearrangement of 2-Amino-4-(trifluoromethyl)oxazoles to Hydantoins.

-5-Halogenation of the oxazoles (I) with one equivalent of bromine initially furnishes 5-bromooxazoles (II) which are further transformed into the 5-acetoxyhydantoins (IV) and (V), respectively. This rearrangement takes place as a major side reaction using one equivalent of bromine and proceeds in higher yields using two equivalents of bromine.