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ChemInform Abstract: Reactivity of Thioaldehyde: Cyclization Reaction of 6-Amino-1,3- dimethyl-5-thioformyluracil with Enamines into Pyrido(2,3-d)pyrimidine- 2,4-(1H,3H)-diones.

✍ Scribed by K. HIROTA; K. KUBO; H. SAJIKI; Y. KITADE; M. SAKO; Y. MAKI

Publisher: John Wiley and Sons
Year: 2010
Weight: 31 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199737176

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✦ Synopsis

Reactivity of Thioaldehyde:

Cyclization Reaction of 6-Amino-1,3-dimethyl-5-thioformyluracil with Enamines into Pyrido(2,3d)pyrimidine-2,4-(1H,3H)-diones.

-The thioaldehyde (I) reacts with electron-rich morpholino enamines under mild condition to afford pyridopyrimidines of type (III) in a regioselective manner. With electron-poor morpholino enamines as well as with the corresponding aldehyde no cyclization occurs. -

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