## Abstract A simple method for the synthesis of dihydropyridine‐fused 1,3‐diazaheterocycles based on the reaction of heterocyclic ketene aminals with acrylonitrile and subsequent intramolecular cyclization of the addition products (III) is developed.
ChemInform Abstract: Reactions of Heterocyclic Ketene Aminals with Dimethyl Oxalate: A Facile Synthesis of γ-Lactam-Fused 1,3-Diazaheterocycles.
✍ Scribed by C.-Y. YU; L.-B. WANG; W.-Y. LI; Z.-T. HUANG
- Book ID
- 112041329
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 32 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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📜 SIMILAR VOLUMES
Heterocyclic ketene aminals 1-3 react with benzyl chloride to give the benzyl-substituted compounds 4-6. With ethyl bromoacetate, 1 -3 react smoothly, and y-iactam-fused heterobicycles 9-11 are obtained by further cyclocondensation of the alkylation products.
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