## Abstract A simple method for the synthesis of dihydropyridineβfused 1,3βdiazaheterocycles based on the reaction of heterocyclic ketene aminals with acrylonitrile and subsequent intramolecular cyclization of the addition products (III) is developed.
Reaction of Heterocyclic Ketene Aminals with Bis(methylthio)methylene Malononitrile: Synthesis of Polyfunctionalized Pyridine-Fused 1,3-Diazaheterocycles from Heterocyclic Ketene Aminals.
β Scribed by Jiang-Peng Liao; Ti Zhang; Chu-Yi Yu; Zhi-Tang Huang
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 20 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
Heterocyclic ketene aminals 1-3 react with benzyl chloride to give the benzyl-substituted compounds 4-6. With ethyl bromoacetate, 1 -3 react smoothly, and y-iactam-fused heterobicycles 9-11 are obtained by further cyclocondensation of the alkylation products.