ChemInform Abstract: Reaction of 5-Aroylamino-1,3,4-thiadiazole-2(3H)-thiones with Hydrazonoyl Chlorides.
โ Scribed by M. A. ABDALLAH; M. A. N. MOSSELHI; I. M. ABBAS; A.-G. A. FAHMI; A. S. SHAWALI
- Book ID
- 112025067
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 26 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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## Preparation of New 5-Aroylamino Substituted 3-Nicotinoyl/Isonicotinoyl-1,3,4-thiadiazol-2(3H)-ones with Antiinflammatory Activity. -All the title compounds (V), especially (Vb) and (Vc), exhibit anti-inflammatory activity and are devoid of antipyretic properties.
Synthesis and Molecular Structure of 5-(1-Aminoisoindolenin-3ylideneamino)-1,3,4-thiadiazole-2(3H)-thione. -During recrystallization of the macrocyclic compound (I), a hydrolytic cleavage occurs to afford the title compound (II) containing an isoindole and a thiadiazole cycle. This compound (II) is