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ChemInform Abstract: Pyrrolo[2′,3′:4,5]furo[3,2-c]pyridine Derivatives. Reactions in the Pyridine and Pyrrole Ring.

✍ Scribed by M. Benckova; A. Krutosikova; J. Pullman; N. Pronayova

Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

Pyrrolo[2',3':4,5]

furo [3,2-c]pyridine Derivatives.

Reactions in the Pyridine and Pyrrole Ring.

-The reactivity of the title fused system in some simple reactions is studied. Oxidation of the pyridine nitrogen in compound (I) is easily achieved in the presence of MCPBA. The formed N-oxide smoothly undergoes α-cyanation (Reissert-Henze reaction) in the system KCN-Ph-CO-Cl. Additionally, hydrazides (VI), obtained by reaction of the corresponding esters (V) with excess hydrazine, serve as excellent educts for the synthesis of potentially biologically active pyridofuropyrrolotriazines (VIII). -

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Furopyridines. Part 27. Reactions of 2-Methyl and 2-Cyano Derivatives of Furo[2,3-b]-, -[3,2-b]-, -[2,3-c]-and -[3,2-c]pyridine. -Ongoing interest in the chemistry of furopyridines leads to the investigation of different reactions with the title compounds. Bromination of the 2-cyano derivatives of