ChemInform Abstract: Pseudosugars. Part 39. Synthesis of Methyl 5a′-Carba-β-lactoside and N-Acetyl-5a′-carba-β-lactosaminides, and Related 5a′-Carbadisaccharides.
✍ Scribed by S. OGAWA; K. HIRAI; T. ODAGIRI; N. MATSUNAGA; T. YAMAZAKI; A. NAKAJIMA
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 48 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Synthesis of Methyl 5a'-Carba-βlactoside and N-Acetyl-5a'-carba-β-lactosaminides, and Related 5a'-Carbadisaccharides.
-The title compounds, e.g. (X) and (XV), which are potential enzyme inhibitors, are prepared using consecutive epimerization reactions as the key steps.
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Pseudosugars. Part 40. Synthesis of Ether-and Imino-Linked Octyl N-Acetyl-5a'-carba-β-lactosaminides and -isolactosaminides: Acceptor Substrates for α-(1→3/4)-Fucosyltransferase, and Enzymatic Synthesis of 5a'-Carbatrisaccharides.
Synthesis of ether-linked octyl 5aЈ-carba-β-lactosaminide 3 substrate for human-milk α-(1Ǟ3/4)-fucosyltransferase and, interestingly, 5 is not. In addition, the imino-linked and -isolactosaminide 5 was carried out in seven steps, starting from the coupling products of 1,2-anhydro-5a-carba-congeners
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