ChemInform Abstract: Process Research and Development of L-Alanyl-L-glutamine, a Component of Parenteral Nutrition.
β Scribed by Takahiro Sano; Toru Sugaya; Kunimi Inoue; Sho-ichi Mizutaki; Yasuyuki Ono; Masaji Kasai
- Publisher
- John Wiley and Sons
- Year
- 2000
- Weight
- 28 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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Process Research for the Synthesis of RWJ-51204, a Novel Anxiolytic Agent. -A safe large-scale synthesis of title compound (I) is developed involving an improved final alkylation step, that generates the potentially toxic alkylating chloromethyl ethyl ether in situ, eliminates the use of 15-crown-5