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ChemInform Abstract: Process Development of a Novel Antiinflammatory Agent. The Regiospecific Bromination of 4′-Acetylmethanesulfonanilide.

✍ Scribed by A. ZANKA; A. KUBOTA; S. HIRABAYASHI; H. NAKAMURA


Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
29
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Process Research fo
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Process Research for the Synthesis of RWJ-51204, a Novel Anxiolytic Agent. -A safe large-scale synthesis of title compound (I) is developed involving an improved final alkylation step, that generates the potentially toxic alkylating chloromethyl ethyl ether in situ, eliminates the use of 15-crown-5