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ChemInform Abstract: Preparation of Optically Active N-Benzyl-3-hydroxypyrrolidine by Enzymatic Hydroxylation.

โœ Scribed by Zhi Li; Hans-Juergen Feiten; Jan B. van Beilen; Wouter Duetz; Bernard Witholt

Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
30
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Preparation of Optically Active N-Benzyl-3-hydroxypyrrolidine by Enzymatic Hydroxylation.

-Various alkane-degrading microorganisms, which are known to contain an alkane hydroxylase system, are tested for their ability to hydroxylate N-benzylpyrrolidine (I) to the target N-benzylhydroxypyrrolidine derivative (II). The best results are obtained for HXN-1100 and HXN-200 strains, which provide the (R)-or the (S)enantiomer in 70% and 53% optical purity, resp., and in good yields.

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