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ChemInform Abstract: Preparation of Optically Active Cyanohydrins Using the (S)- Hydroxynitrile Lyase from Hevea brasiliensis.

✍ Scribed by M. SCHMIDT; S. HERVE; N. KLEMPIER; H. GRIENGL


Book ID
112037886
Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
27
Category
Article
ISSN
0931-7597

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Absrruct: (S')-13-Hydroxyoctadeca-(9Z, I I,?)-dienoic acid (1) was synthesized in nine steps starting from (Q-2-octenal (2). The (S)-hydroxynitrile lyase cloned from Hewa brasiliensis, that has been overexpressed in Pi&a pastoris, was used to interconvert 2 into (S)-cyanohydrin 3, The subsequent but