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ChemInform Abstract: Preparation and Properties of Enantiomerically Pure Nα-Tritylamino Acid Fluorides.

✍ Scribed by G. KARYGIANNIS; C. ATHANASSOPOULOS; P. MAMOS; N. KARAMANOS; D. PAPAIOANNOU; G. W. FRANCIS

Publisher
John Wiley and Sons
Year
2010
Weight
38 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

Preparation and Properties of Enantiomerically Pure N α -Tritylamino Acid Fluorides.

-Acyl fluorides of type (II) and (XI), prepared by fluorination of amino acids with cyanuric fluoride (CNF), are powerful acylating agents for peptide synthesis. Their reactivity is further demonstrated by reaction with phosphorane (V), Ruppert's reagent (VII), and NaBH 4 , providing access to enantiomerically pure, alkene (VI), trifluoromethyl ketone (IX), and tritylamino alcohol (XII), respectively. -(KARYGIANNIS, G.; ATHANASSOPOULOS,

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