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ChemInform Abstract: Phenyloxazoles and Phenylthiazoles as Benzamide Bioisosteres: Synthesis and Dopamine Receptor Binding Profiles.

โœ Scribed by Juergen Einsiedel; Christoph Thomas; Harald Huebner; Peter Gmeiner

Publisher
John Wiley and Sons
Year
2000
Weight
26 KB
Volume
31
Category
Article
ISSN
0931-7597

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2,2-Dicyanovinyl as a Nonaromatic Aryl Bioisostere: Synthesis, Binding Experiments, and SAR Studies of Highly Selective Dopamine D4 Receptor Ligands. -Title compounds of type (I) are tested for their dopamine receptor binding activity. Both types of 4-or 5-substituted compounds show selective dopami