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ChemInform Abstract: Phenoxypyrimidine Inhibitors of p38α Kinase: Synthesis and Statistical Evaluation of the p38 Inhibitory Potencies of a Series of 1-(Piperidin-4-yl)-4-(4-fluorophenyl)-5-(2-phenoxypyrimidin-4-yl) Imidazoles.

✍ Scribed by Jeffrey C. Boehm; Michael J. Bower; Timothy F. Gallagher; Shouki Kassis; Stephen R. Johnson; Jerry L. Adams


Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
32
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Synthesis and Biolo
✍ T. D. PENNING; J. J. TALLAY; S. R. BERTENSHAW; J. S. CARTER; P. W. COLLINS; S. D 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-(5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide (SC-58635, Celecoxib). -Claisen condensation, followed by regioselective reaction with the hydrochloride