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ChemInform Abstract: P450BM3 (CYP102A1): Connecting the Dots

✍ Scribed by Christopher J. C. Whitehouse; Stephen G. Bell; Luet-Lok Wong


Book ID
112043563
Publisher
John Wiley and Sons
Year
2012
Weight
18 KB
Volume
43
Category
Article
ISSN
0931-7597

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Figure 1. Product distributions in the oxidation of alkylbenzenes by wildtype CYP102A1 (WT) and variant KT5 (F87A7A330P/E377A/D425N).

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## Abstract The oxidation of __o__‐xylene by P450~BM3~ from __Bacillus megaterium__ yields, in addition to the products formed by microsomal P450s, two metabolites containing an NIH‐shifted methyl group, one of which lacks the aromatic character of the substrate. The failure of the epoxide precurso