ChemInform Abstract: Organic Base-Catalyzed Stereodivergent Synthesis of (R)- and (S)-3-Amino-4,4,4-trifluorobutanoic Acids.
β Scribed by Norio Shibata; Takayuki Nishimine; Naoyuki Shibata; Etsuko Tokunaga; Kosuke Kawada; Takumi Kagawa; Alexander E. Sorochinsky; Vadim A. Soloshonok
- Book ID
- 112048826
- Publisher
- John Wiley and Sons
- Year
- 2012
- Weight
- 38 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
An efficient synthesis of the non-proteinogenic amino acid (2R,3S)-4,4,4-trifluoro(OBn)-threonine is described. Starting with commercially available (S)-Garner's aldehyde, the desired amino acid was prepared as its hydrochloride salt in five steps and an overall yield of 33% (59% based on recovered
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