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ChemInform Abstract: Optimization of a Somatostatin Mimetic via Constrained Amino Acid and Backbone Incorporation.

✍ Scribed by Andrew J. Souers; Asa Rosenquist; Emma M. Jarvie; Mark Ladlow; Wasyl Feniuk; Jonathan A. Ellman


Publisher
John Wiley and Sons
Year
2001
Weight
28 KB
Volume
32
Category
Article
ISSN
0931-7597

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Synthesis of Constrained Ξ±-Amino Acid Derivatives via Enyne Metathesis Reaction. -Ring-closing metathesis of the enyne (VI), prepared following an optimized approach, in the presence of Grubb's catalyst gives the vinylcyclopentene (VII). The latter undergoes Diels-Alder reaction with the appropriat