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ChemInform Abstract: One-Pot Three-Component Catalytic Synthesis of Fully Substituted Pyrroles from Readily Available Propargylic Alcohols, 1,3-Dicarbonyl Compounds and Primary Amines.

✍ Scribed by Victorio Cadierno; Jose Gimeno; Noel Nebra


Publisher
John Wiley and Sons
Year
2008
Weight
57 KB
Volume
39
Category
Article
ISSN
0931-7597

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## Abstract A simple and highly efficient method for the preparation of fully substituted pyrroles, from readily accessible secondary propargylic alcohols, 1,3‐dicarbonyl compounds and primary amines, has been developed. The one‐pot multicomponent reaction, which is catalysed by the system [Ru(Ξ·^3^

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## Abstract magnified image Several tetrasubstituted Nο£ΏH pyrroles, functionalized with ester or ketone groups at C‐3 position, were prepared by one‐pot coupling of secondary propargylic alcohols with 1,3‐dicarbonyl compounds and __tert__‐butyl carbamate, __via__ __in situ__ deprotection of the cor