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ChemInform Abstract: One-Pot Synthesis of Benzothiazolines and Naphthathiazolines via Cascade ortho-Lithiation, Cyclization and Elimination of N-Arylsulfonyl Lactams.

✍ Scribed by John D. Harling; Patrick G. Steel; Tom. M. Woods; Dmitry S. Yufit


Publisher
John Wiley and Sons
Year
2008
Weight
49 KB
Volume
39
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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ChemInform Abstract: One-Pot Synthesis o
✍ Keith Smith; Gamal A. El-Hiti; Amany S. Hegazy πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 22 KB

## Abstract Lithiation of ureas (I) and (VI) followed by quenching with various electrophiles, such as aldehydes (II), ketones (IV) and alkyl halides (VII) affords the corresponding 3‐substituted isoindolin‐1‐ones (III), (V), and (VIII), respectively, in good yields.