## Abstract Two efficient methods for the preparation of 2β(2βsulfanylβ4__H__β3,1βbenzothiazinβ4βyl)acetic acid derivatives **3** under mild conditions have been developed. The first method is based on the reaction of 3β(2βisothiocyanatophenyl)propβ2βenoates **1a**β**1c** with thiols in the presenc
ChemInform Abstract: One-Pot Syntheses of 2-(2-Sulfanyl-4H-3,1-benzothiazin-4-yl)acetic Acid Derivatives via Reactions of 3-(2-Isothiocyanatophenyl)prop-2-enoic Acid Derivatives with Thiols or Sodium Sulfide.
β Scribed by Shuhei Fukamachi; Hisatoshi Konishi; Kazuhiro Kobayashi
- Publisher
- John Wiley and Sons
- Year
- 2011
- Weight
- 50 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
Title compounds can be synthesized by two different pathways.
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## Abstract The multicomponent reaction between oxopropylbenzoate(acetate) (I), (VI), primary amines (II), (Nβisocyanimino)triphenylphosphorane (III), and aromatic carboxylic acids (IV) proceeds smoothly at room temperature under neutral conditions to afford the sterically congested oxadiazole deri