ChemInform Abstract: One-Pot Reduction of Carboxylic Acids via O-Acylisoureas.

✍ Scribed by J. M. HERBERT; A. T. HEWSON; J. E. PEACE

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 30 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199827044

✦ Synopsis

One-Pot Reduction of Carboxylic Acids via O-Acylisoureas.

-A simple one-pot conversion of carboxylic acids to primary alcohols is reported. Functional groups like nitro, amides, and carbamates as well as double bonds are tolerated. Aromatic carboxylic acids like (III) give a mixture of the alcohol (V) and the N-cyclohexylcarboxamides (VI). -(HERBERT,